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Basimglurant

CAT: 1410-M22362-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1410-M22362-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Basimglurant is a potent, selective and orally available modulator of mGlu5 negative allosteric (Kd of 1.1 nM) . In competition binding experiments on human recombinant mGlu5, Basimglurant (RG7090) fully displaces [3H]-MPEP with a Ki of 35.6 nM and [3H]-ABP688 with a Ki of 1.4 nM. In HEK293 cells stably expressing human mGlu5, Basimglurant (RG7090) inhibits quisqualate induced Ca2+ mobilization with an IC50 of 7.0 nM and [3H]-inositolphosphate accumulation (IC50 of 5.9 nM) .
CAS Number
802906-73-6
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
325.77
Molecular Formula
C18H13ClFN3
Notes
Research use only, not for human use.
Receptor
MGlu5

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HY-15446-01Basimglurant
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A21225-200Basimglurant 200mg
A21225-100Basimglurant 100mg
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HY-15446R-01Basimglurant (Standard)
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