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Basimglurant (Standard)

CAT: 0804-HY-15446R-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15446R-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Basimglurant (Standard) is the analytical standard of Basimglurant. This product is intended for research and analytical applications. Basimglurant (RG7090) is a potent, selective and orally available mGlu5 negative allosteric modulator with a Kd of 1.1 nM[1]. Basimglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
802906-73-6
UNSPSC
12352100
Target
MGluR; Reference Standards
Related Pathways
GPCR/G Protein; Neuronal Signaling; Others
Field of Research
Neurological Disease
Smiles
CC1=C(C#CC2=CC(Cl)=NC=C2)N=C(C)N1C3=CC=C(F)C=C3
Molecular Formula
C18H13ClFN3
Molecular Weight
325.77
References & Citations
[1]Lindemann L, et al. Pharmacology of basimglurant (RO4917523, RG7090), a unique metabotropic glutamate receptor 5 negative allosteric modulator in clinical development for depression. J Pharmacol Exp Ther. 2015 Apr;353 (1) :213-33.|[2]Jaeschke G, et al. Metabotropic glutamate receptor 5 negative allosteric modulators: discovery of 2-chloro-4-[1- (4-fluorophenyl) -2,5-dimethyl-1H-imidazol-4-ylethynyl]pyridine (basimglurant, RO4917523), a promising novel medicine for psychiatric diseases.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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