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HLM006474

CAT: 1410-M22127-07Size: 100 mgDry Ice: NoHazardous: No
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CAT#:1410-M22127-07Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HLM006474 is a pan inhibitor of E2F. This inhibits E2F4 DNA-binding (IC50: 29.8 µM in A375 cells) .HLM006474 causes the viability of both SCLC and NSCLC lines (IC50 ranging from 15 to 75 µM) . HLM006474 displays little activities against E2F4 DNA-binding in A375 cells at 10 and 20 µM, apparently inhibits E2F4 DNA-binding at 40 µM, and increasingly suppresses the effect at 60 and 80 µM concentrations.
CAS Number
353519-63-8
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
399.48
Molecular Formula
C25H25N3O2
Notes
Research use only, not for human use.
Receptor
E2F4 DNA-binding

Chemical Information

7-[(4-Ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol
CAS Number353519-63-8
PubChem CID2895500
IUPAC Name7-[(4-ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol
Molecular FormulaC25H25N3O2
Molecular Weight399.5
XLogP5.4
Topological Polar Surface Area67.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count30
Formal Charge0
Complexity533
SMILES
CCOC1=C(C=C(C=C1)C(C2=C(C3=C(C=CC(=N3)C)C=C2)O)NC4=CC=CC=N4)C
InChI
InChI=1S/C25H25N3O2/c1-4-30-21-13-11-19(15-16(21)2)23(28-22-7-5-6-14-26-22)20-12-10-18-9-8-17(3)27-24(18)25(20)29/h5-15,23,29H,4H2,1-3H3,(H,26,28)
InChIKey
CYNZBLNMIJNBSF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 7-[(4-Ethoxy-3-methylphenyl)-(pyridin-2-ylamino)methyl]-2-methylquinolin-8-ol
CAS: 353519-63-8
CID: 2895500
Formula: C25H25N3O2
MW: 399.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight399.5
XLogP35.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass399.19467705
Monoisotopic Mass399.19467705
Topological Polar Surface Area67.3 Ų
Heavy Atom Count30
Formal Charge0
Complexity533
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS5754963HLM006474
A20921-500HLM006474 500mg
A20921-100HLM006474 100mg
A20921-5HLM006474 5mg
A20921-50HLM006474 50mg
A20921-25HLM006474 25mg

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