HLM006474

• Description :

  HLM006474 is a pan inhibitor of E2F. This inhibits E2F4 DNA-binding (IC50: 29.8 µM in A375 cells) .HLM006474 causes the viability of both SCLC and NSCLC lines (IC50 ranging from 15 to 75 µM) . HLM006474 displays little activities against E2F4 DNA-binding in A375 cells at 10 and 20 µM, apparently inhibits E2F4 DNA-binding at 40 µM, and increasingly suppresses the effect at 60 and 80 µM concentrations.

• Stability :

  ≥ 2 years

• Purity :

  >98% (HPLC)

• Weight :

  399.48

• Molecular Formula :

  C25H25N3O2

• Notes :

  Research use only, not for human use.

• Receptor :

  E2F4 DNA-binding

• CAS Number :

  353519-63-8