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Binimetinib

CAT: 1410-M15269-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:1410-M15269-01Size:5 mg
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Description
Binimetinib (MEK162, ARRY-162, ARRY-438162) is a potent inhibitor of MEK1/2 with IC50 of 12 nM in a cell-free assay. Phase 3.
CAS Number
606143-89-9
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
441.23
Molecular Formula
C17H15BrF2N4O3
Notes
Research use only, not for human use.
Receptor
MEK

Chemical Information

Binimetinib

Binimetinib is a member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib. It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor. It is a member of benzimidazoles, a member of bromobenzenes, a secondary amino compound, a hydroxamic acid ester and a member of monofluorobenzenes.

CAS Number606143-89-9
PubChem CID10288191
IUPAC Name6-(4-bromo-2-fluoroanilino)-7-fluoro-N-(2-hydroxyethoxy)-3-methylbenzimidazole-5-carboxamide
Molecular FormulaC17H15BrF2N4O3
Molecular Weight441.2
XLogP3.1
Topological Polar Surface Area88.4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Heavy Atom Count27
Formal Charge0
Complexity521
SMILES
CN1C=NC2=C1C=C(C(=C2F)NC3=C(C=C(C=C3)Br)F)C(=O)NOCCO
InChI
InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
InChIKey
ACWZRVQXLIRSDF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Binimetinib
CAS: 606143-89-9
CID: 10288191
Formula: C17H15BrF2N4O3
MW: 441.2
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight441.2
XLogP33.1
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count7
Rotatable Bond Count6
Exact Mass440.02956
Monoisotopic Mass440.02956
Topological Polar Surface Area88.4 Ų
Heavy Atom Count27
Formal Charge0
Complexity521
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
bs-83020C-01Binimetinib
HY-15202S1-01Binimetinib-d3
C12377-1gBinimetinib (MEK162)
AR-B07254-01Binimetinib Glucuronide
HY-15202S3Binimetinib-d4
HY-15202R-01Binimetinib (Standard)
TRC-B655730-250MGBinimetinib Hydroxylamine
SD5951-10mMBinimetinib (MEK inhibitor)
TRC-N890670-5MGN-Nitroso Binimetinib

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