Products for Research Use Only
RegisterLogin

PS-1145

CAT: 1410-M14463-07Size: 100 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:1410-M14463-07Size:100 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
A specific IκB kinase (IKK) inhibitor with IC50 of 88 nM.
CAS Number
431898-65-6
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
322.7484
Molecular Formula
C17H11ClN4O
Notes
Research use only, not for human use.
Receptor
IKK

Chemical Information

N-(6-chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide

PS-1145 is a member of the class of beta-carbolines that is 9H-beta-carboline substituted by chloro and (pyridin-3-ylcarbonyl)amino groups at positions 6 and 8, respectively. It is a IB kinase beta (IKKbeta) inhibitor (IC50 = 88 nM). It has a role as an antineoplastic agent, an apoptosis inducer and an EC 2.7.11.10 (IkappaB kinase) inhibitor. It is a secondary carboxamide, a pyridinecarboxamide, an organochlorine compound and a member of beta-carbolines.

CAS Number431898-65-6
PubChem CID9949093
IUPAC NameN-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)pyridine-3-carboxamide
Molecular FormulaC17H11ClN4O
Molecular Weight322.7
XLogP2.7
Topological Polar Surface Area70.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Heavy Atom Count23
Formal Charge0
Complexity448
SMILES
C1=CC(=CN=C1)C(=O)NC2=CC(=CC3=C2NC4=C3C=CN=C4)Cl
InChI
InChI=1S/C17H11ClN4O/c18-11-6-13-12-3-5-20-9-15(12)21-16(13)14(7-11)22-17(23)10-2-1-4-19-8-10/h1-9,21H,(H,22,23)
InChIKey
JZRMBDHPALEPDM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(6-chloro-9h-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide
CAS: 431898-65-6
CID: 9949093
Formula: C17H11ClN4O
MW: 322.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight322.7
XLogP32.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count2
Exact Mass322.0621387
Monoisotopic Mass322.0621387
Topological Polar Surface Area70.7 Ų
Heavy Atom Count23
Formal Charge0
Complexity448
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
M30629M 1145
M20508-01TMB-PS
M17170-01PS 48
M10840-01PS 210
M13247-01PS-432
M10841-01PS 423
M23348-01PS-47
M421892B- (pS)
M10293-01DEBIO 1143
M33602-01GP2-114

Alternative Products

CatalogName
HY-18008-01PS-1145
MBS131770PS 1145
sc-301621PS-1145 dihydrochloride
GTR19200971-01PS 1145 dihydrochloride
A12789-500PS-1145 500mg
A12789-100PS-1145 100mg
A12789-25PS-1145 25mg
A12789-10PS-1145 10mg

Popular Products