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GDC-0927 R-form

CAT: 1410-M12491Size: 1 EachDry Ice: NoHazardous: No
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CAT#:1410-M12491Size:1 Each
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Description
GDC-0927 (SRN-927, RG-6047) is a potent, orally bioavailable, selective estrogen receptor degrader (SERD) .
CAS Number
1642297-53-7
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
461.533
Molecular Formula
C28H28FNO4
Notes
Research use only, not for human use.
Receptor
Estrogen Receptor/ERR

Chemical Information

(R)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
CAS Number1642297-53-7
PubChem CID87054925
IUPAC Name(2R)-2-[4-[2-[3-(fluoromethyl)azetidin-1-yl]ethoxy]phenyl]-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
Molecular FormulaC28H28FNO4
Molecular Weight461.5
XLogP4.7
Topological Polar Surface Area62.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Heavy Atom Count34
Formal Charge0
Complexity703
SMILES
CC1=C([C@H](OC2=C1C=C(C=C2)O)C3=CC=C(C=C3)OCCN4CC(C4)CF)C5=CC(=CC=C5)O
InChI
InChI=1S/C28H28FNO4/c1-18-25-14-23(32)7-10-26(25)34-28(27(18)21-3-2-4-22(31)13-21)20-5-8-24(9-6-20)33-12-11-30-16-19(15-29)17-30/h2-10,13-14,19,28,31-32H,11-12,15-17H2,1H3/t28-/m1/s1
InChIKey
KJAAPZIFCQQQKX-MUUNZHRXSA-N
Chemical Structure
2D Structure
2D structure of (R)-2-(4-(2-(3-(fluoromethyl)azetidin-1-yl)ethoxy)phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-chromen-6-ol
CAS: 1642297-53-7
CID: 87054925
Formula: C28H28FNO4
MW: 461.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight461.5
XLogP34.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count6
Rotatable Bond Count7
Exact Mass461.20023654
Monoisotopic Mass461.20023654
Topological Polar Surface Area62.2 Ų
Heavy Atom Count34
Formal Charge0
Complexity703
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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A19747-50GDC-0927 50mg
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