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BMS-754807

CAT: 1410-M10014-01Size: 2 mgDry Ice: NoHazardous: No
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CAT#:1410-M10014-01Size:2 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BMS-754807 (BMS 754807, BMS754807) is a potent, reversible, orally active inhibitor of IGF-1R/Insulin receptor with IC50 of 1.8 and 1.7 nM, respectively.
CAS Number
1001350-96-4
Stability
≥ 2 years
Purity
>98% (HPLC)
Weight
461.4948
Molecular Formula
C23H24FN9O
Notes
Research use only, not for human use.
Receptor
IGF-1R|InsulinReceptor|Met|TrkA|TrkB

1001350-96-4

PubChem
cas1001350-96-4
modify2026-05-17
descriptionBMS-754807 is a pyrrolotriazine that is pyrrolo[2,1-f][1,2,4]triazine which is substituted at position 2 by the pyrrolidine nitrogen of (2S)-N-(6-fluoropyridin-3-yl)-2-methylprolinamide, and at position 4 by a (5-cyclopropyl-1H-pyrazol-3-yl)amino group. It is a potent, reversible inhibitor of the insulin-like growth factor 1 receptor/insulin receptor family kinases. It has a role as an antineoplastic agent and an EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor. It is a member of pyrazoles, a member of pyridines, a member of pyrrolidines and a pyrrolotriazine.
synonyms
BMS-7548071001350-96-4BMS 754807BMS754807W9E3353E8JBMS-754807-01
(2S)-1-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl]-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide
CHEBI:88339
(2S)-1-{4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]pyrrolo[2,1-f][1,2,4]triazin-2-yl}-N-(6-fluoropyridin-3-yl)-2-methylpyrrolidine-2-carboxamide
2-PYRROLIDINECARBOXAMIDE, 1-(4-((5-CYCLOPROPYL-1H-PYRAZOL-3-YL)AMINO)PYRROLO(2,1-F)(1,2,4)TRIAZIN-2-YL)-N-(6-FLUORO-3-PYRIDINYL)-2-METHYL-, (2S)-
+ 15 more
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A1185-100BMS-754807
RM-B131901-01Bms 754807

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