IGUANA-1 (free base)

IGUANA-1 (free base)

• CAS Number: 2756014-24-9
• UNSPSC Description: IGUANA-1 free base (STL5-T-0057) is an selective ALDH1 B1 inhibitor with an IC50 value of 30 nM. IGUANA-1 free base inhibits cell growth of SW480 cells in adherent and spheroid conditions with IC50 values of 2.46 and 0.39 μM, respectively. IGUANA-1 free base can be used for the research of cancer[1].
• Target Antigen: Aldehyde Dehydrogenase (ALDH)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/iguana-1-free-base.html
• Solubility: 10 mM in DMSO
• Smiles: ClC1=CC(OC)=C(C2=CN(C3=NCCCN32)C4=CC=C(C5=C(OC)C=CC=C5)C=C4)C=C1
• Molecular Weight: 445.94
• References & Citations: [1]Chen Jame Kenneth, et al. Preparation of substituted imidazolium or cyclic guanidine compounds as isoform-specific aldehyde dehydrogenase inhibitors for the treatment of cancer. WO2021257696 A1. 2021.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported