Human CXCL10 (IP-10) Recombinant Protein

• Background:

  CXCL10, also known as Interferon gamma-induced protein 10 or small-inducible cytokine B10, is a member of the C-X-C chemokine family. CXCL10 is secreted by several cell types in response to IFN-gamma. These cell types include monocytes, endothelial cells and fibroblasts. CXCL10 has been attributed to several roles, such as chemoattraction for monocytes/macrophages, T cells, NK cells, and dendritic cells, promotion of T cell adhesion to endothelial cells, antitumor activity, and inhibition of bone marrow colony formation and angiogenesis. There have been 17 different C-X-C chemokines described in mammals, that are subdivided into two categories, those with a specific amino acid sequence (or motif) of glutamic acid-leucine-arginine (or ELR for short) immediately before the first cysteine of the C-X-C motif (ELR-positive), and those without an ELR motif (ELR-negative) . ELR-positive C-X-C chemokines specifically induce the migration of neutrophils, and interact with chemokine receptors CXCR1 and CXCR2. C-X-C chemokines that lack the ELR motif are chemoattractant for lymphocytes. CXCL10 elicits its effects by binding to the cell surface chemokine receptor CXCR3.

• Description:

  The Human CXCL10 yeast-derived recombinant protein is not tagged and is naturally endotoxin-free. The purity is greater than 98% as visualized by SDS-PAGE analysis. Human CXCL10 applications are for cell culture, ELISA standard, and Western Blot Control. The Human CXCL10 yeast-derived recombinant protein can be purchased in multiple sizes. Human CXCL10 Specifications: (Molecular Weight: 8.6 kDa) (Amino Acid Sequence: VPLSRTVRCT CISISNQPVN PRSLEKLEII PASQFCPRVE IIATMKKKGE KRCLNPESKA IKNLLKAVSK ERSKRSP (77) ) (Gene ID: 3627) . For research use only.

• Applications:

  Cell Culture, ELISA Standard, ELISpot Control, Western Blot Control

• Homology:

  Gorilla gorilla gorilla (western lowland gorilla), Homo sapiens (human), Hylobates moloch (silvery gibbon), Pan paniscus (pygmy chimpanzee), Pan troglodytes (chimpanzee)

• Storage Temperature:

  -20°C