IP-10 (CXCL10)

• Description:

  IP-10 is a CXC chemokine that signals through the CXCR3 receptor. IP-10 selectively chemoattracts Th1 lymphocytes and monocytes, and inhibits cytokine-stimulated hematopoietic progenitor cell proliferation. Additionally, it is angiostatic and mitogenic for vascular smooth muscle cells. Recombinant rat IP-10 is an 8.6 kDa protein consisting of 77 amino acids including the four conserved cysteine residues present in CXC chemokines.

• Synonyms:

  Gamma-Interferon inducible protein 10, CXCL10, crg-2

• NCBI Gene ID:

  245920

• UniProt:

  P48973

• Accession Number:

  NP_620789.1

• Accession Number mRNA:

  NM_139089.1

• Chromosomal Location:

  14p22

• Reactivity:

  Rat

• Cross Reactivity:

  Rat, Human

• Sequence:

  IPLARTVRCT CIDFHEQPLR PRAIGKLEII PASLSCPHVE IIATMKKNNE KRCLNPESEA IKSLLKAVSQ RRSKRAP

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract hCXCR3/HEK293 cells using a concentration range of 10.0-50.0 ng/ml.

• Length:

  77

• Form:

  Lyophilized

• Molecular Weight:

  8.6 kDa

• Host or Source:

  E. coli