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Recombinant Human papillomavirus 31 Protein E7 (E7)

CAT: 0399-CSB-EP324626HND-01Size: 20 µgDry Ice: NoHazardous: No
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CAT#:0399-CSB-EP324626HND-01Size:20 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Product Name Alternative
E7
Abbreviation
Recombinant Human papillomavirus 31 E7 protein
Gene Name
E7
UniProt
P17387
Expression Region
1-98aa
Organism
Human papillomavirus 31
Target Sequence
MRGETPTLQDYVLDLQPEATDLHCYEQLPDSSDEEDVIDSPAGQAEPDTSNYNIVTFCCQCKSTLRLCVQSTQVDIRILQELLMGSFGIVCPNCSTRL
Tag
C-terminal 6xHis-tagged
Type
In Stock Protein
Source
E.coli
Field of Research
Others
Relevance
E7 protein has both transforming and trans-activating activities. Disrupts the function of host retinoblastoma protein RB1/pRb, which is a key regulator of the cell cycle. Induces the disassembly of the E2F1 transcription factors from RB1, with subsequent transcriptional activation of E2F1-regulated S-phase genes. Inactivation of the ability of RB1 to arrest the cell cycle is critical for cellular transformation, uncontrolled cellular growth and proliferation induced by viral infection. Stimulation of progression from G1 to S phase allows the virus to efficiently use the cellular DNA replicating machinery to achieve viral genome replication. Interferes with histone deacetylation mediated by HDAC1 and HDAC2, leading to activation of transcription
Endotoxin
Not test
Purity
Greater than 95% as determined by SDS-PAGE.
Activity
Not Test
Form
Liquid or Lyophilized powder
Buffer
If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Molecular Weight
17.8 kDa
Storage Conditions
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Protein Length
Full Length

UniProtKB · P17387

Protein E7

VE7_HPV31 · Human papillomavirus 31

View on UniProt ↗
Primary accession
P17387
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
E7
Protein existence
1: Evidence at protein level
Organism
Human papillomavirus 31
Taxonomy ID
10585
Alternative names
—
EC number
—
Processing
—
Secondary accessions
—
Protein keywords

Molecular function

ActivatorDNA-binding

Developmental stage

Early protein

Biological process

G1/S host cell cycle checkpoint dysregulation by virusHost-virus interactionInhibition of host innate immune response by virusInhibition of host interferon signaling pathway by virusInterferon antiviral system evasionModulation of host cell cycle by virusTranscriptionTranscription regulationViral immunoevasion

Cellular component

Host cytoplasmHost nucleus

Ligand

Metal-bindingZinc

Disease

Oncogene

Technical term

Reference proteome

Domain

Zinc-finger

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