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Norharman-d7

CAT: 0804-HY-W700241Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-W700241Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Norharman-d7 is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings[1][2][3][4][5][6][7].
CAS Number
1216503-21-7
UNSPSC
12352005
Target
Endogenous Metabolite; Isotope-Labeled Compounds; Monoamine Oxidase
Type
Isotope-Labeled Compounds
Related Pathways
Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Cancer; Infection; Neurological Disease
Smiles
[2H]C1=C(C([2H])=C(C2=C1C3=C(C([2H])=NC([2H])=C3[2H])N2)[2H])[2H]
Molecular Formula
C11HD7N2
Molecular Weight
175.24
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Herraiz T, et al. Human monoamine oxidase enzyme inhibition by coffee and beta-carbolines norharman and harman isolated from coffee. Life Sci. 2006 Jan 18;78 (8) :795-802.|[3]López-González D, et al. A natural indole alkaloid, norharmane, affects PIN expression patterns and compromises root growth in Arabidopsis thaliana. Plant Physiol Biochem. 2020 Jun;151:378-390.|[4]Ebrahimi-Ghiri M, et al. Anxiolytic and antidepressant effects of ACPA and harmaline co-treatment. Behav Brain Res. 2019 May 17;364:296-302. |[5]Saito K, Chen CY, Masana M, Crowley JS, Markey SP, Heyes MP. 4-Chloro-3-hydroxyanthranilate, 6-chlorotryptophan and norharmane attenuate quinolinic acid formation by interferon-gamma-stimulated monocytes (THP-1 cells) . Biochem J. 1993 Apr 1;291 (Pt 1) (Pt 1) :11-4. |[6]Paul BK, et al. Binding of norharmane with RNA reveals two thermodynamically different binding modes with opposing heat capacity changes. J Colloid Interface Sci. 2019 Mar 7;538:587-596. |[7]Luo HZ, et al. Inhibitory effect of norharmane on Serratia marcescens NJ01 quorum sensing-mediated virulence factors and biofilm formation. Biofouling. 2021 Feb;37 (2) :145-160.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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