TWEAK receptor, soluble

• Description:

  TWEAK-R belongs to the TNF family of transmembrane proteins and contains a cytoplasmic „death domain“, which can activated the cell's apoptotic machinery. It is expressed in the spleen, thymus, peripheral blood lymphocytes, colon, and small intestine. Signal transduction by TWEAK-R can be activated by either the membrane anchored or the soluble TWEAK. Recombinant soluble TWEAK-R is a 53 amino acid polypeptide (5.6 kDa) comprising the entire extracellular domain of the full length TWEAK-R protein.

• Synonyms:

  TNFRSF12A; FN14; CD266; TWEAKR

• NCBI Gene ID:

  51330

• UniProt:

  Q9NP84

• Accession Number:

  NP_057723.1

• Accession Number mRNA:

  NM_016639.2

• Chromosomal Location:

  16p13.3

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  EQAPGTAPCS RGSSWSADLD KCMDCASCRA RPHSDFCLGC AAAPPAPFRL LWP

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to inhibit TWEAK-induced weak cell death of HT29 cells. The expected ED50 for this effect is 1.0-3.0 µg/ml.

• Length:

  53

• Form:

  Lyophilized

• Molecular Weight:

  5.6 kDa

• Host or Source:

  E. coli