BAFF receptor, soluble

• Description:

  BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B) . BAFF-R/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFF-R is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extracellular portion of the full BAFF-R protein.

• Synonyms:

  TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin

• NCBI Gene ID:

  115650

• UniProt:

  Q96RJ3

• Accession Number:

  NP_443177

• Accession Number mRNA:

  NM_052945

• Chromosomal Location:

  22q13.1-q13.31

• Reactivity:

  Human

• Cross Reactivity:

  Mouse

• Sequence:

  MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2.0-4.0 μg/ml in the presence of 1.0 μg/ml of human soluble BAFF.

• Length:

  76

• Form:

  Lyophilized

• Molecular Weight:

  7.7 kDa

• Host or Source:

  E. coli