BAFF receptor, soluble

• Description :

  BAFF Receptor (BAFF-R), a member of the TNFR superfamily, is highly expressed in spleen, lymph node, and resting B cells and to some extent in activated B cells, resting CD4+ cells and peripheral blood leukocytes. BAFF-R is a type III transmembrane protein that binds with high specificity to BAFF (TNFSF13B) . BAFF-R/BAFF signaling plays a critical role in B cell survival and maturation. Recombinant human BAFF-R is a 76 amino acid polypeptide (7.7 kDa) corresponding to the extracellular portion of the full BAFF-R protein.

• Synonyms :

  TNFRSF13C; BAFFR; CD268; CVID4; BAFF-R; BROMIX; prolixin

• NCBI Gene ID :

  115650

• UniProt :

  Q96RJ3

• Accession Number :

  NP_443177

• Accession Number mRNA :

  NM_052945

• Chromosomal Location :

  22q13.1-q13.31

• Reactivity :

  Human

• Cross Reactivity :

  Mouse

• Sequence :

  MRRGPRSLRG RDAPAPTPCV PAECFDLLVR HCVACGLLRT PRPKPAGASS PAPRTALQPQ ESVGAGAGEA ALPLPG

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to block BAFF induced mouse splenocyte survival. The expected ED50 for this effect is 2.0-4.0 μg/ml in the presence of 1.0 μg/ml of human soluble BAFF.

• Length :

  76

• Form :

  Lyophilized

• Molecular Weight :

  7.7 kDa

• Host or Source :

  E. coli