Relaxin-2

• Description:

  Relaxin-2 is a peptide hormone structurally related to insulin, which is expressed in the placenta, decidua, prostate, and in the ovary during pregnancy. Of the three known relaxin genes, Relaxin-2 is the only relaxin known to circulate in the blood. Relaxin-2 binds specifically to the LGR7 and LGR8 receptors, previously identified as an “orphan” G protein coupled receptors. Signaling by Relaxin-2 through its target receptors enhances the growth of pubic ligaments and ripening of the cervix during birth. Recombinant Relaxin-2 is a nonglycosylated 6.0 kDa disulfide linked heterodimeric protein consisting of a 24 amino acid A-chain and a 29 amino acid B-chain.

• Synonyms:

  H2 relaxin, RLN2

• NCBI Gene ID:

  6019

• UniProt:

  P04090

• Accession Number:

  NP_005050.2

• Accession Number mRNA:

  NM_005059.3

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  A-Chain: QLYSALANKC CHVGCTKRSL ARFC; B-Chain: DSWMEEVIKL CGRELVRAQI AICGMSTWS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Data not available.

• Length:

  53

• Form:

  Lyophilized

• Molecular Weight:

  6.0 kDa

• Host or Source:

  E. coli