RANTES (CCL 5)

• Description:

  RANTES is a CC-chemokine that can signal through the CCR1, CCR3, CCR5 and US28 (cytomegalovirus receptor) receptors. It is a chemoattractant towards monocytes, memory T cells (CD4+/CD45RO), basophils, and eosinophils. RANTES also has the capability to inhibit certain strains of HIV-1, HIV-2 and simian immunodeficiency virus (SIV) . Recombinant murine RANTES is a 7.8 kDa protein containing 68 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

• Synonyms:

  Ccl5; SISd; Scya5; RANTES; TCP228; MuRantes

• NCBI Gene ID:

  20304

• UniProt:

  P30882

• Accession Number:

  NP_038681.2

• Accession Number mRNA:

  NM_013653.3

• Chromosomal Location:

  11 C; 11 47.4 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Rat, Mouse, Leech, Human, Bacteria

• Sequence:

  SPYGSDTTPC CFAYLSLALP RAHVKEYFYT SSKCSNLAVV FVTRRNRQVC ANPEKKWVQE YINYLEMS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract total human lymphocyte population and total murine T cell population using a concentration range of 1.0-10.0 ng/ml.

• Length:

  68

• Form:

  Lyophilized

• Molecular Weight:

  7.8 kDa

• Host or Source:

  E. coli