Oncostatin M

CAT: 0209-R20-057-L1000Size: 1000 µgDry Ice: NoHazardous: No
CAT#:0209-R20-057-L1000Size:1000 µg
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Description
Oncostatin M (OSM) is a growth and differentiation factor that participates in the regulation of neurogenesis, osteogenesis and hematopoiesis. Produced by activated T cells, monocytes and Kaposi’s sarcoma cells, OSM can exert both stimulatory and inhibitory effects on cell proliferation. It stimulates the proliferation of fibroblasts, smooth muscle cells and Kaposi’s sarcoma cells, but, inhibits the growth of some normal and tumor cell lines. It also promotes cytokine release (e.g. IL-6, GM-CSF and G-CSF) from endothelial cells, and enhances the expression of low-density lipoprotein receptor in hepatoma cells. OSM share several structural and functional characteristics with LIF, IL-6, and CNTF. Human OSM is active on murine cells. Recombinant rat Oncostatin M is a 24-25 kDa protein, containing 215 amino acid residues.
Synonyms
Oncostatin M
NCBI Gene ID
18413
UniProt
P53347
Accession Number
NP_001013383.1
Accession Number mRNA
NM_001013365.2
Reactivity
Rat
Cross Reactivity
Rat, Mouse, Human, Monkey, Bacteria, Gerbil
Sequence
MKRGCSSSSP KLLSQLKSQA NITGNTASLL EPYILHQNLN TLTLRAACTE HPVAFPSEDM LRQLSKPDFL STVHATLGRV WHQLGAFRQQ FPKIQDFPEL ERARQNIQGI RNNVYCMARL LHPPLEIPEP TQADSGTSRP TTTAPGIFQI KIDSCRFLWG YHRFMGSVGR VFEEWGDGSR RSRRHSPLWA WLKGDHRIRP SRSSQSAMLR SLVPR
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Assay #1: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 is 3.0-5.0 μg/ml. Assay #2: Determined by its ability to inhibit Alkaline phosphatase activity of differentiated MC3T3 E1 cells.
Length
215
Form
Lyophilized
Molecular Weight
24.4 kDa
Host or Source
E. coli

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Alternative Products

CatalogName
O6500-10DOncostatin M (OSM, Oncostatin-M)
216867Oncostatin-M (Oncostatin M, OSM)
130722Oncostatin M (OSM, Oncostatin-M, MGC20461)
O6500-07Oncostatin M (OSM, Oncostatin M Precursor)
O6500-10BOncostatin M (OSM, Oncostatin-MP) discontinued
215757OSM (Oncostatin-M, Oncostatin M) discontinued
AP78389Oncostatin-M
549051Oncostatin M
O6500-10B-APCOncostatin M (OSM, Oncostatin-MP) (APC) discontinued
130724-BiotinOncostatin M (OSM, Oncostatin-M, MGC20461) (Biotin)

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