M-CSF

CAT: 0209-R20-050-L1000Size: 1000 µgDry Ice: NoHazardous: No
CAT#:0209-R20-050-L1000Size:1000 µg
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Description
M-CSF is a potent hematopoietic factor produced by a variety of cells including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival of blood monocytes, tissue macrophages and their progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness, and male and female fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. The human is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant rat M-CSF is a 18.1 kDa homodimeric protein containing two 155 amino acid polypeptide subunits.
Synonyms
Csf1
NCBI Gene ID
78965
UniProt
Q6GMN4
Accession Number
NP_076471.3
Accession Number mRNA
NM_023981
Chromosomal Location
2q34
Reactivity
Rat
Cross Reactivity
Mouse, Rat
Sequence
MEVSEHCSHM IGNGHLQILQ QLIDSQMETA CLIEYKFVDQ EQLDDPVCYL KKAFVLVQVI IEETMRFKDN TPNANATERL QELSMKLNSC FIKDYKEQNE ACVQTYKESP LRLLEKIKNF FNETKNFLEK DWNIFSKNCN DSLAKCSSRD VVTKP
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NFS-60 cells is ≤ 5.0 ng/ml, corresponding to a specific activity of ≥ 2 x 105 units/mg.
Length
155
Form
Lyophilized
Buffer
10 mM Sodium Phophate, pH 7.5
Molecular Weight
18.1 kDa
Host or Source
E. coli

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