M-CSF

• Description :

  Granulocyte/Macrophage Colony-Stimulating Factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. CSF-1 induces cells of the monocyte/macrophage lineage. It plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Macrophage Colony Stimulating Factor Human Recombinant produced in E. coli is a disulfide linked homodimer, non-glycosylated, polypeptide chain containing 2 x 159 amino acids and having a total molecular mass of 36.8 KD. M-CSF is purified by proprietary chromatographic techniques.

• Synonyms :

  CSF1; MCSF; CSF-1

• NCBI Gene ID :

  1435

• UniProt :

  P09603

• Accession Number :

  NP_000748.3

• Accession Number mRNA :

  NM_000757

• Chromosomal Location :

  1p21-p13

• Reactivity :

  Human

• Cross Reactivity :

  Monkey, Mouse, Rat, Human

• Sequence :

  MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 95% by SDS-PAGE

• Bioactivity :

  The biological activity was determined by the dose-dependent induction of proliferation in NFS60 cells (Murine myeloid Leukemia cell line) .

• Length :

  159

• Form :

  Lyophilized

• Buffer :

  PBS

• Reconstitution :

  Water

• Molecular Weight :

  36.8 kDa

• Host or Source :

  E. coli

• N Terminal Sequence :

  MEEVS