MIP-3 beta (CCL19)

• Description:

  MIP-3β is a CC chemokine that is expressed in the thymus, lymph nodes and in activated bone marrow stromal cells and signals through the CCR7 receptor. MIP-3β is a chemoattractant for T and B lymphocytes and myeloid progenitor cells. Human MIP-3β is active on murine cells. Mouse urine MIP-3β is a 9.2 kDa protein containing 83 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

• Synonyms:

  Ccl19; ELC; CKb11; MIP3B; Scya19; exodus-3

• NCBI Gene ID:

  24047

• UniProt:

  O70460

• Accession Number:

  NP_036018.1

• Accession Number mRNA:

  NM_011888

• Chromosomal Location:

  4 A5; 4

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Mouse, Monkey, Leech, Rat

• Sequence:

  GANDAEDCCL SVTQRPIPGN IVKAFRYLLN EDGCRVPAVV FTTLRGYQLC APPDQPWVDR IIRRLKKSSA KNKGNSTRRS PVS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human mature dendritic cells using a concentration range of 10.0-100.0 ng/ml.

• Length:

  83

• Form:

  Lyophilized

• Molecular Weight:

  9.2 kDa

• Host or Source:

  E. coli