GM-CSF

• Description:

  GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant murine GM-CSF is a 14.2 kDa globular protein consisting of 125 amino acid residues.

• Synonyms:

  Granulocyte Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-alpha

• NCBI Gene ID:

  12981

• UniProt:

  P01587

• Accession Number:

  NP_034099.2

• Accession Number mRNA:

  NM_009969.4

• Chromosomal Location:

  11 B1.3; 11 29.5 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse

• Sequence:

  MAPTRSPITV TRPWKHVEAI KEALNLLDDM PVTLNEEVEV VSNEFSFKKL TCVQTRLKIF EQGLRGNFTK LKGALNMTAS YYQTYCPPTP ETDCETQVTT YADFIDSLKT FLTDIPFECK KPVQK

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 as determined by the dose-dependent stimulation of the proliferation of murine FDC-P1 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.

• Length:

  125

• Form:

  Lyophilized

• Molecular Weight:

  14.2 kDa

• Host or Source:

  E. coli