KC (CXCL1)

• Description:

  All three isoforms of GRO or KC are CXC chemokines that can signal through the CXCR1 or CXCR2 receptors. The GRO proteins chemoattract and activate neutrophils and basophils. Recombinant murine KC is a 7.8 kDa protein consisting of 72 amino acids including the 'ELR' motif common to the CXC chemokine family that bind to CXCR1 or CXCR2.

• Synonyms:

  CXCL1

• NCBI Gene ID:

  14825

• UniProt:

  P12850

• Accession Number:

  NP_032202.1

• Accession Number mRNA:

  NM_008176.3

• Chromosomal Location:

  5 E-F; 5 51.0 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Human, Rat, Mouse

• Sequence:

  APIANELRCQ CLQTMAGIHL KNIQSLKVLP SGPHCTQTEV IATLKNGREA CLDPEAPLVQ KIVQKMLKGV PK

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract total human neutrophil population using a concentration range of 10.0-100.0 ng/ml.

• Length:

  72

• Form:

  Lyophilized

• Molecular Weight:

  7.8 kDa

• Host or Source:

  E. coli