IL-9

• Description:

  IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin’s disease. Recombinant rat IL-9 is a 14.3 kDa protein of 127 amino acid residues including 10 cysteine residues which are fully conserved between the human murine proteins.

• Synonyms:

  Il19

• NCBI Gene ID:

  116558

• UniProt:

  D4A819

• Accession Number:

  NP_001099217

• Accession Number mRNA:

  NM_001105747

• Chromosomal Location:

  17p14

• Reactivity:

  Rat

• Cross Reactivity:

  Human

• Sequence:

  MQRCSTSWGI QHTSYLIENL KDDPSSKCSC SANVTSCLCL PIPSDDCTTP CFQEGMSQVT NATQQSKFSP FFFRVKRIVE TLKSNKCQFF SCEKPCNQTT AGNTVSFLKS LLKTFQKTEV QVQRSRA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Measured by its ability to enhance MC/9 cell proliferation.

• Length:

  127

• Form:

  Lyophilized

• Molecular Weight:

  14.3 kDa

• Host or Source:

  E. coli