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IL-9

CAT: 0209-M10-069-L1000Size: 1000 µgDry Ice: NoHazardous: No
CAT#:M10-069-L1000Size:1000 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-9 is an immunoregulatory cytokine produced by IL-2 activated Th2 lymphocytes. IL-9 enhances the proliferation of T lymphocytes, mast cells, erthroid precursor cells and megakaryoblastic leukemia cell lines. Over-expression of IL-9 has been implicated in the pathogenesis of anaplastic lymphoma and Hodgkin's disease. Whereas murine IL-9 can function on human cells, human IL-9 is inactive on mouse cells. Recombinant murine IL-9 is a 14.3 kDa protein of 127 amino acid residues including 10 cysteine residues which are fully conserved between the human murine proteins.
Synonyms
Il9; P40; Il-9
NCBI Gene ID
16198
UniProt
P15247
Accession Number
NP_032399.1
Accession Number mRNA
NM_008373
Chromosomal Location
13 B1; 13 35.0 cM
Reactivity
Mouse
Cross Reactivity
Human, Mouse
Sequence
MQRCSTTWGI RDTNYLIENL KDDPPSKCSC SGNVTSCLCL SVPTDDCTTP CYREGLLQLT NATQKSRLLP VFHRVKRIVE VLKNITCPSF SCEKPCNQTM AGNTMSFLKS LLGTFQKTEM QRQKSRP
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent proliferation of human MO7e cells is < 0.5 ng/ml, corresponding to a specific activity of > 2 x 106 units/mg.
Length
127
Form
Lyophilized
Molecular Weight
14.3 kDa
Host or Source
E. coli

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