IL-8 (77aa)

• Description:

  IL-8 is a proinflammatory CXC chemokine that can signal through the CXCR1 and CXCR2 receptors. It is secreted by monocytes and endothelial cells. IL-8 chemoattracts and activates neutrophils. Recombinant human IL-8 (endothelial-derived) is an 8.9 kDa protein containing 77 amino acid residues.

• Synonyms:

  IL8; NAF; GCP1; LECT; LUCT; NAP1; CXCL8; GCP-1; LYNAP; MDNCF; MONAP; NAP-1

• NCBI Gene ID:

  3576

• UniProt:

  P10145

• Accession Number:

  NP_000575.1

• Accession Number mRNA:

  NM_000584.3

• Chromosomal Location:

  4q13-q21

• Reactivity:

  Human

• Cross Reactivity:

  Chicken, Mouse, Human, Bacteria

• Sequence:

  AVLPRSAKEL RCQCIKTYSK PFHPKFIKEL RVIESGPHCA NTEIIVKLSD GRELCLDPKE NWVQRVVEKF LKRAENS

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 25.0-150.0 ng/ml.

• Length:

  77

• Form:

  Lyophilized

• Molecular Weight:

  8.9 kDa

• Host or Source:

  E. coli