IL-7

• Description:

  IL-7 is a hematopoietic growth factor which affects primarily early B and T cells. Produced by thymic stromal cells, spleen cells and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors such as ConA and IL-2. Human and murine IL-7 is cross-species reactive. Recombinant murine IL-7 is a 15.0 kDa protein containing 130 amino acid residues.

• Synonyms:

  Il7; Il-7; hlb368; A630026I06Rik

• NCBI Gene ID:

  16196

• UniProt:

  P10168

• Accession Number:

  NP_032397.1

• Accession Number mRNA:

  NM_008371

• Chromosomal Location:

  3 A1; 3 6.6 cM

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse, Human

• Sequence:

  MECHIKDKEG KAYESVLMIS IDELDKMTGT DSNCPNNEPN FFRKHVCDDT KEAAFLNRAA RKLKQFLKMN ISEEFNVHLL TVSQGTQTLV NCTSKEEKNV KEQKKNDACF LKRLLREIKT CWNKILKGSI

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 as determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is < 0.2 ng/ml, corresponding to a specific activity of > 5 x 106 units/mg.

• Length:

  130

• Form:

  Lyophilized

• Molecular Weight:

  15 kDa

• Host or Source:

  E. coli