IL-7

• Description :

  IL-7 is a hematopoietic growth factor which affects primarily early B and T cells. Produced by thymic stromal cells, spleen cells and keratinocytes, IL-7 can also co-stimulate the proliferation of mature T cells in combination with other factors such as ConA and IL-2. Human and murine IL-7 is cross-species reactive. Recombinant human IL-7 is a 17.4 kDa protein containing 153 amino acid residues.

• Synonyms :

  IL7; IL-7

• NCBI Gene ID :

  3574

• UniProt :

  P13232

• Accession Number :

  NP_000871.1

• Accession Number mRNA :

  NM_000880

• Chromosomal Location :

  8q12-q13

• Reactivity :

  Human

• Cross Reactivity :

  Monkey, Mouse, Rat, Human, Leech

• Sequence :

  MDCDIEGKDG KQYESVLMVS IDQLLDSMKE IGSNCLNNEF NFFKRHICDA NKEGMFLFRA ARKLRQFLKM NSTGDFDLHL LKVSEGTTIL LNCTGQVKGR KPAALGEAQP TKSLEENKSL KEQKKLNDLC FLKRLLQEIK TCWNKILMGT KEH

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  The ED50 was determined by the dose-dependent stimulation of the proliferation of murine 2E8 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.

• Length :

  153

• Form :

  Lyophilized

• Buffer :

  10 mM Acetic Acid

• Molecular Weight :

  17.4 kDa

• Host or Source :

  E. coli