IL-6

CAT: 0209-R20-008-L500Size: 500 µgDry Ice: NoHazardous: No
CAT#:0209-R20-008-L500Size:500 µg
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AVAILABILITY
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
IL-6 is a pleiotropic cytokine that plays an important role in host defense by regulating immune and inflammatory responses. Produced by T cells, monocytes, fibroblasts, endothelial cells and keratinocytes, IL-6 has diverse biological functions. It stimulates B-cell differentiation and antibody production, synergizes with IL-3 in megakaryocyte development and platelet production, induces expression of hepatic acute-phase proteins, and regulates bone metabolism. IL-6 signals through the IL-6 receptor system that consists of two chains, IL-6R α and gp130. Murine IL-6 is inactive on human cells, while both human and murine are equally active on murine cells. Recombinant rat IL-6 is a 21.7 kDa protein containing 187 amino acid residues.
Synonyms
Il6; ILg6; Ifnb2
NCBI Gene ID
24498
UniProt
P20607
Accession Number
NP_036721
Accession Number mRNA
NM_012589
Chromosomal Location
4q11
Reactivity
Rat
Cross Reactivity
Mouse, Bacteria, Rat, Human
Sequence
MFPTSQVRRG DFTEDTTHNR PVYTTSQVGG LITYVLREIL EMRKELCNGN SDCMNSDDAL SENNLKLPEI QRNDGCFQTG YNQEICLLKI CSGLLEFRFY LEFVKNNLQD NKKDKARVIQ SNTETLVHIF KQEIKDSYKI VLPTPTSNAL LMEKLESQKE WLRTKTIQLI LKALEEFLKV TMRSTRQT
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
The ED50 as determined by the dose-dependent stimulation of the proliferation of IL-6-dependent murine 7TD1 cells is < 0.01 ng/ml, corresponding to a specific activity of > 1 x 108 units/mg.
Length
187
Form
Lyophilized
Molecular Weight
21.7 kDa
Host or Source
E. coli