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IL-36 gamma (IL-1F9)

CAT: 0209-100-092-L1000Size: 1000 μgDry Ice: NoHazardous: No
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CAT#:0209-100-092-L1000Size:1000 μg
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Description
The IL-1 family is comprised of 11 structurally related ligands, including recently re-named IL-36 α (IL-1F6), β (IL-1F8) and γ (IL-1F9) . IL-36γ is highly expressed in psoriatic plaques and in tissues containing epithelial cells. IL-36γ signals through the IL-1Rrp2 (IL-1R6) receptor, which is primarily expressed on certain dendritic cells. The interaction of the IL-1Rrp2 receptor with IL-36 ligands induces dendritic cell maturation and activation. IL-36γ also functions as an agonist of NF-kappaB, and can stimulate the inflammatory response in bronchial epithelial cells. Recombinant human IL-36γ is a 17.0 kDa protein containing 152 amino acid residues.
Synonyms
IL1E; IL1F9; IL1H1; IL-1F9; IL-1H1; IL1RP2; IL-1RP2
NCBI Gene ID
56300
UniProt
Q9NZH8
Accession Number
NP_062564.1
Accession Number mRNA
NM_019618.3
Chromosomal Location
2q12-q21
Reactivity
Human
Cross Reactivity
Human
Sequence
SMCKPITGTI NDLNQQVWTL QGQNLVAVPR SDSVTPVTVA VITCKYPEAL EQGRGDPIYL GIQNPEMCLY CEKVGEQPTL QLKEQKIMDL YGQPEPVKPF LFYRAKTGRT STLESVAFPD WFIASSKRDQ PIILTSELGK SYNTAFELNI ND
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Measured by its ability to induce IL-8 production by human PBMCs.
Length
152
Form
Lyophilized
Molecular Weight
17 kDa
Host or Source
E. coli

UniProtKB · Q9NZH8

Interleukin-36 gamma

IL36G_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9NZH8
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
IL36G
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q56B91, Q6UVX7, Q7RTZ9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Molecular function

Cytokine

Cellular component

CytoplasmSecreted

Biological process

ImmunityInflammatory responseInnate immunity

Related Products

CatalogName
101-M500IL-1F9
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100-091-L250IL-36 beta (IL-1F8)
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100-160-L100IL-36 alpha (IL-1F6)
100-160IL-36 alpha (IL-1F6)
100-091-L500IL-36 beta (IL-1F8)
100-160-L1000IL-36 alpha (IL-1F6)

Alternative Products

CatalogName
MBS8533023-01Interleukin-36 gamma/IL-36 gamma/IL-1F9
HY-P72544-01IL-36 gamma/IL-1F9, Mouse
HY-P70670-01IL-36 gamma/IL-1F9, Human
MBS691854-01Human IL-36 gamma (IL-1F9)
2320-IL-025Recombinant Human IL-36 gamma/IL-1F9
P516235IL-36 gamma; IL-1F9 Protein (Mouse)
GTR18289369IL-36 gamma (IL-1F9) Antibody (biotin)
HY-P75861IL-36 gamma/IL-1F9, Human (His)
PKSM041397-01Recombinant Mouse Interleukin-36 gamma/IL-36 gamma/IL-1F9
NBP2-41388-0.01mgRecombinant Mouse IL-36 gamma/IL-1F9 Protein

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