Recombinant Mouse Interleukin-36 gamma/IL-36 gamma/IL-1F9

• Background:

  Interleukin-36 gamma (IL-36γ) is a member of the interleukin 1 cytokine family that includes three closely related genes, IL-36α, β, and γ, formerly known as IL-1F6, F8, and F9 respectively. IL-36α has been detected in both neuronal and synovial tissue, whereas IL-36β and IL-36γ are expressed in both cutaneous and mucosal epithelial cells, including the respiratory tract. IL-36β and IL-36γ stimulate proliferation, maturation and/or cytokine expression by innate immune cells (such as keratinocytes and dendritic cells), and adaptive immune cells (neutrophils and T-cells) in both humans and mice. The activity of IL-36α is mediated by interleukin 1 receptor-like 2 (IL1RL2/IL1R-rp2), and is specifically inhibited by interleukin 1 family, member 5 (IL1F5/IL-1 delta) . IL-36γ plays an important role in communicating the cell death to surrounding cells.

• Abbreviation:

  IL-36 gamma; IL-1F9

• Synonyms:

  Il1f; IL-1-related protein; Interleukin-1 homolog; IL-1F; IL-1H; IL-1RP; IL-1 epsilon; IL-1F9; IL-1H1; IL-1-related protein 2; IL-1RP2; Interleukin-1 homolog 1; Interleukin-36 gamma; Il1f9; Il36g; IL-17E

• UniProt:

  Q8R460

• Accession Number:

  Q8R460

• Expression System:

  E.coli

• Tag:

  None

• Sequence:

  Gly13-Ser164

• Endotoxin:

  < 1.0 EU per μg of the protein as determined by the LAL method.

• Purity:

  > 95 % as determined by reducing SDS-PAGE.

• Bioactivity:

  Not validated for activity

• Reconstitution:

  Please refer to the printed manual for detailed information.

• Shipping Conditions:

  This product is provided as lyophilized powder which is shipped with ice packs.

• Storage Conditions:

  Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

• Calculated Molecular Weight:

  17.3 kDa

• Observed Molecular Weight:

  17 kDa

• Species:

  Mouse