IL-34

• Description:

  IL-34 is a homodimeric cytokine that is expressed in a range of tissues including spleen, heart, brain, liver, kidney, lung, ovary, thymus, testis, small intestine, prostate and colon. IL-34 is a ligand for colony-stimulating factor-1 receptor (CSF1R), which also binds to CSF-1. It specifically binds CD14+ monocytes, promotes survival and proliferation of human peripheral blood monocytes, and stimulates macrophage colony formation by human bone marrow cells. IL-34, like human CSF-1 stimulates phosphorylation of MAPK1/ERK2 and MAPK3/ERK1. Recombinant human IL-34 is a 52.5 kDa homodimeric glycoprotein consisting of 460 amino acid residues, including a C-terminal His-Tag.

• Synonyms:

  IL34; IL-34; C16orf77

• NCBI Gene ID:

  146433

• UniProt:

  Q6ZMJ4

• Accession Number:

  NP_689669.2

• Accession Number mRNA:

  NM_152456.2

• Chromosomal Location:

  16q22.1

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Label:

  His-tag

• Sequence:

  NEPLEMWPLT QNEECTVTGF LRDKLQYRSR LQYMKHYFPI NYKISVPYEG VFRIANVTRL QRAQVSEREL RYLWVLVSLS ATESVQDVLL EGHPSWKYLQ EVETLLLNVQ QGLTDVEVSP KVESVLSLLN APGPNLKLVR PKALLDNCFR VMELLYCSCC KQSSVLNWQD CEVPSPQSCS PEPSLQYAAT QLYPPPPWSP SSPPHSTGSV RPVRAQGEGL LPHHHHHHHH

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Measured by its ability to induce secretion of MCP-1 from PBMCs.

• Length:

  460

• Form:

  Lyophilized

• Molecular Weight:

  52.5 kDa

• Host or Source:

  HEK 293 cells