IL-33

• Description:

  IL-33 is a proinflammatory protein that shares structural and functional characteristics with the IL-1 cytokine family. It binds and signals through the IL-1RL1/ST2 receptor activating NF-kappaB and MAP kinases. IL-33 induces production of TH2 cell related cytokines, including IL-4, IL-5 and IL-13, and exerts multiple inflammation related bioactivities. Recombinant murine IL-33 is a 17.5 kDa protein containing 158 amino acid residues.

• Synonyms:

  NF-HEV

• NCBI Gene ID:

  77125

• UniProt:

  Q8BVZ5

• Accession Number:

  NP_598536.2

• Accession Number mRNA:

  NM_133775.2

• Chromosomal Location:

  19; 19 C2

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse

• Sequence:

  SIQGTSLLTQ SPASLSTYND QSVSFVLENG CYVINVDDSG KDQEQDQVLL RYYESPCPAS QSGDGVDGKK LMVNMSPIKD TDIWLHANDK DYSVELQRGD VSPPEQAFFV LHKKSSDFVS FECKNLPGTY IGVKDNQLAL VEEKDESCNN IMFKLSKI

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  The ED50 was determined by the dose-dependent stimulation of the proliferation of murine D10S cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106units/mg.

• Length:

  158

• Form:

  Lyophilized

• Molecular Weight:

  17.5 kDa

• Host or Source:

  E. coli