IL-31

• Description:

  IL-31 is a T-cell derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (GP130-like, IL-31RA) and OSMR (Oncostatin M receptor) . GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, Jak1, and Jak2 signaling pathways. IL-31 regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant murine IL-31 is a 15.8 kDa protein containing 140 amino acid residues.

• Synonyms:

  Il31; 1700013B14Rik

• NCBI Gene ID:

  76399

• UniProt:

  Q6EAL8

• Accession Number:

  NP_083870.1

• Accession Number mRNA:

  NM_029594

• Chromosomal Location:

  5 F; 5

• Reactivity:

  Mouse

• Cross Reactivity:

  Mouse

• Sequence:

  MTCSLSFGAP ISKEDLRTTI DLLKQESQDL YNNYSIKQAS GMSADESIQL PCFSLDREAL TNISVIIAHL EKVKVLSENT VDTSWVIRWL TNISCFNPLN LNISVPGNTD ESYDCKVFVL TVLKQFSNCM AELQAKDNTT C

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Testing in progress.

• Length:

  140

• Form:

  Lyophilized

• Molecular Weight:

  15.8 kDa

• Host or Source:

  E. coli