IL-17E

• Description:

  IL-17E is a disulfide-linked homodimer of two 145 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region, but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17E stimulated secretion of IL-8, and induces activation of the transcription factor NK-kB in cells that express the IL-17BR receptor. Recombinant human IL-17E is a 33.8 kDa disulfide-linked homodimer of two 145 amino acid polypeptide chains.

• Synonyms:

  IL25; IL17E

• NCBI Gene ID:

  64806

• UniProt:

  Q9H293

• Accession Number:

  NP_073626.1

• Accession Number mRNA:

  NM_022789

• Chromosomal Location:

  14q11.2

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  MYSHWPSCCP SKGQDTSEEL LRWSTVPVPP LEPARPNRHP ESCRASEDGP LNSRAISPWR YELDRDLNRL PQDLYHARCL CPHCVSLQTG SHMDPRGNSE LLYHNQTVFY RRPCHGEKGT HKGYCLERRL YRVSLACVCV RPRVMG

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10-100ng.

• Length:

  145

• Form:

  Lyophilized

• Molecular Weight:

  33.8 kDa

• Host or Source:

  E. coli