IL-17B

• Description :

  IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-alpha and IL-1beta from cells of the monocyte lineage. Recombinant human IL-17B is a 36.6 kDa disulfide-linked homodimer of two 161 amino acid polypeptide chains.

• Synonyms :

  IL17B; NIRF; IL-20; IL-17B; ZCYTO7

• NCBI Gene ID :

  27190

• UniProt :

  Q9UHF5

• Accession Number :

  NP_055258.1

• Accession Number mRNA :

  NM_014443

• Chromosomal Location :

  5q33.1

• Reactivity :

  Human

• Cross Reactivity :

  Human

• Sequence :

  MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng. Please Note: Results may vary with PBMC donors.

• Length :

  161

• Form :

  Lyophilized

• Molecular Weight :

  36.6 kDa

• Host or Source :

  E. coli