IL-17B

• Description:

  IL-17B is a disulfide-linked homodimer of two 161 amino acid polypeptide chains. It belongs to the IL-17 family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17B is expressed by T-cells and has been shown to stimulate release of TNF-alpha and IL-1beta from cells of the monocyte lineage. Recombinant human IL-17B is a 36.6 kDa disulfide-linked homodimer of two 161 amino acid polypeptide chains.

• Synonyms:

  IL17B; NIRF; IL-20; IL-17B; ZCYTO7

• NCBI Gene ID:

  27190

• UniProt:

  Q9UHF5

• Accession Number:

  NP_055258.1

• Accession Number mRNA:

  NM_014443

• Chromosomal Location:

  5q33.1

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Sequence:

  MQPRSPKSKR KGQGRPGPLA PGPHQVPLDL VSRMKPYARM EEYERNIEEM VAQLRNSSEL AQRKCEVNLQ LWMSNKRSLS PWGYSINHDP SRIPVDLPEA RCLCLGCVNP FTMQEDRSMV SVPVFSQVPV RRRLCPPPPR TGPCRQRAVM ETIAVGCTCI F

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to induce IL-8 in human PBMCs using a concentration range of 10ng-100ng. Please Note: Results may vary with PBMC donors.

• Length:

  161

• Form:

  Lyophilized

• Molecular Weight:

  36.6 kDa

• Host or Source:

  E. coli