IL-17A

• Description :

  The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.

• Synonyms :

  IL-17, CTLA-8

• NCBI Gene ID :

  16171

• UniProt :

  Q62386

• Accession Number :

  NP_034682.1

• Accession Number mRNA :

  NM_010552.3

• Chromosomal Location :

  1; 1 A

• Reactivity :

  Mouse

• Cross Reactivity :

  Rat, Mouse, Human

• Sequence :

  AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA

• Endotoxin :

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity :

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity :

  Measured by its ability to induce IL-6 production by NIH 3T3 cells.

• Length :

  133

• Form :

  Lyophilized

• Molecular Weight :

  30 kDa

• Host or Source :

  E. coli