IL-17A

• Description:

  The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.

• Synonyms:

  IL-17, CTLA-8

• NCBI Gene ID:

  16171

• UniProt:

  Q62386

• Accession Number:

  NP_034682.1

• Accession Number mRNA:

  NM_010552.3

• Chromosomal Location:

  1; 1 A

• Reactivity:

  Mouse

• Cross Reactivity:

  Rat, Mouse, Human

• Sequence:

  AAIIPQSSAC PNTEAKDFLQ NVKVNLKVFN SLGAKVSSRR PSDYLNRSTS PWTLHRNEDP DRYPSVIWEA QCRHQRCVNA EGKLDHHMNS VLIQQEILVL KREPESCPFT FRVEKMLVGV GCTCVASIVR QAA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Measured by its ability to induce IL-6 production by NIH 3T3 cells.

• Length:

  133

• Form:

  Lyophilized

• Molecular Weight:

  30 kDa

• Host or Source:

  E. coli