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GM-CSF

CAT: 0013-GTR19068733-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19068733-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Granulocyte-macrophage colony stimulating factor (GM-CSF) is an important hematopoietic growth factor first identified as an inducer of differentiation and proliferation of granulocytes and macrophages derived from haematopoietic progenitor cells. Later studies have shown that GM-CSF is involved in a wide range of biological processes in both innate and adaptive immunity, with its production being tightly linked to the response to danger signals. GM-CSF is primarily produced by multiple cell types such as activated T cells, B cells, macrophages, monocytes, mast cells, vascular endothelial cells, and fibroblasts. GM-CSF (CSF2R) receptor is composed of an α-subunit which binds GM-CSF with low affinity (GMRα) and a signal-transducing βc-subunit which is shared with the IL-3 and IL-5 receptors. There are many signaling pathways triggered by CSF2R, including Jak/STAT, PI3K, ERK1/2, and NF-kB pathways. GM-CSF has shown potential as a new and important therapeutic target in several autoimmune and inflammatory disorders-particularly in rheumatoid arthritis.
Field of Research
Immunology & Inflammation
Purity
≥95%
Molecular Weight
1769.01
Notes
For research use only.
AA Sequence
NAIQEARRLLNLSRD

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