GITR Protein (His & AVI Tag), Biotinylated

• Description:

  GITR, also known as TNFRSF18 (CD357), belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is the receptor for TNFSF18. GITR plays a key role in dominant immunological self-tolerance maintained by CD25 (+) CD4 (+) regulatory T cells. GITR may be involved in interactions between activated T-lymphocytes and endothelial cells and in the regulation of T-cell receptor-mediated cell death. GITR and its ligand are important costimulatory molecules in the pathogenesis of autoimmune diseases. It also mediates NF-kappa-B activation via the TRAF2/NIK pathway.

• Synonyms:

  AITR Protein; CD357 Protein; ENERGEN Protein; GITR Protein; GITR-D Protein; UNQ319/PRO364 Protein

• Accession Number:

  NP_683700.1

• Reactivity:

  Human

• Cross Reactivity:

  Human

• Label:

  His-/AVI-Tag

• Assay Protocol:

  See Datasheet send with the product

• Endotoxin:

  < 1.0 EU per μg protein as determined by the LAL method.

• Purity:

  > 95 % as determined by SDS-PAGE.

• Bioactivity:

  Immobilized Human GITRL mFc at 2 μg/mL (100 μL/well) can bind Human GITR, Biotinylated, the EC50 is 15-90 ng/mL.

• Length:

  162

• Form:

  Lyophilized

• Buffer:

  PBS, pH 7.4

• Reconstitution:

  See Datasheet

• Molecular Weight:

  29 kDa (glycosylated)

• Storage Conditions:

  Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

• Host or Source:

  HEK 293 cells