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GDF-5 (BMP-14/CDMP-1)

CAT: 0209-100-389-L100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-100-389-L100Size:100 µg
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Description
GDF-5 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Mutations in this gene are associated with acromesomelic dysplasia, Hunter-Thompson type; brachydactyly, type C; and chondrodysplasia, Grebe type. These associations confirm that the gene product plays a role in skeletal development. GDF-5 produced in E.Coli is a homodimer, non-glycosylated, polypeptide chain containing 2 x 120 amino acids and having a total molecular mass of 26.8 Dalton.
Synonyms
GDF5; OS5; LAP4; BMP14; CDMP1; SYNS2
NCBI Gene ID
8200
UniProt
P43026
Accession Number
NP_000548
Accession Number mRNA
NM_000557
Chromosomal Location
20q11.2
Reactivity
Human
Cross Reactivity
Human
Sequence
APLATRQGKR PSKNLKARCS RKALHVNFKD MGWDDWIIAP LEYEAFHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS ANNVVYKQYE DMVVESCGCR
Purity
> 98% by SDS-PAGE & RP-HPLC
Bioactivity
The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1.0-2.0 µg/ml.
Length
120
Form
Lyophilized
Molecular Weight
26.8 kDa
Host or Source
E. coli

UniProtKB · P43026

Growth/differentiation factor 5

GDF5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P43026
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GDF5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GDF-5
EC number
—
Processing
Precursor
Secondary accessions
E1P5Q2, Q96SB1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Cellular component

Cell membraneMembraneSecreted

Biological process

Chondrogenesis

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoprotein

Molecular function

CytokineGrowth factor

Disease

Disease variantDwarfism

Domain

Signal

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Alternative Products

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RC444263Mouse GDF-5 (BMP-14/CDMP-1)
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MBS692747-01Human GDF-5 (BMP-14/CDMP-1, Animal Free)
BMP141-SAnti-Human BMP-14 (CDMP-1/GDF-5) antiserum
BMP141-CHuman recombinant, purified BMP-14 (CDMP-1/GDF-5) protein control for WB
143344-01GDF-5, Recombinant, Human (BMP-14, Cartilage-Derived Morphogenetic Protein-1 (CDMP-1) )
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