FGF-17

• Description:

  FGF-17 is a heparin binding growth factor that is a member of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-17 signals through the FGFR 1c, 2c, 3c, and 4. FGF-17 signals induction and patterning of embryonic brain. Recombinant human FGF-17 is a 22.7 kDa protein consisting of 195 amino acid residues.

• Synonyms:

  FGF17; FGF-13

• NCBI Gene ID:

  8822

• UniProt:

  O60258

• Accession Number:

  NP_003858

• Accession Number mRNA:

  NM_003867

• Chromosomal Location:

  9p21

• Reactivity:

  Human

• Cross Reactivity:

  Mouse

• Sequence:

  MTQGENHPSP NFNQYVRDQG AMTDQLSRRQ IREYQLYSRT SGKHVQVTGR RISATAEDGN KFAKLIVETD TFGSRVRIKG AESEKYICMN KRGKLIGKPS GKSKDCVFTE IVLENNYTAF QNARHEGWFM AFTRQGRPRQ ASRSRQNQRE AHFIKRLYQG QLPFPNHAEK QKQFEFVGSA PTRRTKRTRR PQPLT

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 95% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 0.5 ng/ml (≥ 2 x 106 units/mg. Assay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 10 ng/ml (≥ 1 x 105 units/mg) .

• Length:

  195

• Form:

  Lyophilized

• Molecular Weight:

  22.7 kDa

• Host or Source:

  E. coli