FGF acidic

CAT: 0209-M10-045-L1000Size: 1000 µgDry Ice: NoHazardous: No
CAT#:0209-M10-045-L1000Size:1000 µg
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Description
FGF-acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors. Recombinant mouse FGF-acidic is a 15.9 kDa protein consisting of 141 amino acid residues.
Synonyms
HBGF-1; aFGF; acidic fibroblast growth factor; fibroblast growth factor 1 (acidic) ; heparin-binding growth factor 1
NCBI Gene ID
14164
UniProt
P61148
Accession Number
NP_034327.1
Accession Number mRNA
NM_010197.3
Chromosomal Location
18 19.0 cM
Reactivity
Mouse
Cross Reactivity
Mouse
Sequence
MFNLPLGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SAGEVYIKGT ETGQYLAMDT EGLLYGSQTP NEECLFLERL EENHYNTYTS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 98% by SDS-PAGE & HPLC analyses
Bioactivity
Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by 3T3 cells in the presence of heparin is ≤ 0.5 ng/ml (≥ 2 x 106 units/mg) . Assay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 0.2 ng/ml in the presence of 10 μg/ml heparin (≥ 5 x 106 units/mg)
Length
141
Form
Lyophilized
Molecular Weight
15.9 kDa
Host or Source
E. coli

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