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FGF acidic

CAT: 0209-100-016-L250Size: 250 µgDry Ice: NoHazardous: No
CAT#:0209-100-016-L250Size:250 µg
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Description
FGF-acidic is one of 23 known members of the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-acidic is a non-glycosylated heparin binding growth factor that is expressed in the brain, kidney, retina, smooth muscle cells, bone matrix, osteoblasts, astrocytes and endothelial cells. FGF-acidic has the ability to signal through all the FGF receptors. Recombinant human FGF-acidic is a 15.8 kDa protein consisting of 140 amino acid residues.
Synonyms
FGF2; BFGF; FGFB; HBGF-2
NCBI Gene ID
2246
UniProt
P05230
Accession Number
NP_000791.1
Accession Number mRNA
NM_000800.4
Chromosomal Location
5q31
Reactivity
Human
Cross Reactivity
Cow, Mouse, PIG, Rat, Human, Hamster, Leech
Sequence
MFNLPPGNYK KPKLLYCSNG GHFLRILPDG TVDGTRDRSD QHIQLQLSAE SVGEVYIKST ETGQYLAMDT DGLLYGSQTP NEECLFLERL EENHYNTYIS KKHAEKNWFV GLKKNGSCKR GPRTHYGQKA ILFLPLPVSS D
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
> 95% by SDS-PAGE & HPLC analyses
Bioactivity
Assay #1: The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors is ≤ 10 ng/ml. Assay #2: The ED50 was determined by a cell proliferation assay using balb/c 3T3 cells is ≤ 0.5 ng/ml in the presence of 10 μg/ml heparin.
Length
141
Form
Lyophilized
Molecular Weight
15.8 kDa
Host or Source
E. coli

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