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Fetuin-A/AHSG

CAT: 0209-100-140-L100Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0209-100-140-L100Size:100 µg
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Description
Fetuin A/AHSG is a human plasma glycoprotein belonging to the Cystatin family of proteases inhibitors. It is highly expressed in embryonic cells and adult hepatocytes, and is expressed to a lesser extent in monocytes/macrophages. Fetuin A/AHSG is a major serum protein component that exerts various calcium dependent physiological activities, and can mediate growth signaling in certain tumor cells. It also can act as a natural antagonist against specific TGF-β and BMP signaling proteins, Recombinant human Fetuin-A is a heterodimeric protein containing a 282 amino acid A chain and a 27 amino acid B chain. Due to glycosylation, recombinant Fetuin-A migrates at an apparent molecular weight of 45 – 55 kDa by SDS-PAGE run under non-reducing conditions.
Synonyms
Alpha-2-HS-glycoprotein, Alpha-2-Z-globulin, Ba-alpha-2-glycoprotien
NCBI Gene ID
197
UniProt
P02765
Accession Number
NP_001613
Accession Number mRNA
NM_001622.2
Chromosomal Location
3q27
Reactivity
Human
Cross Reactivity
Human
Sequence
APHGPGLIYR QPNCDDPETE EAALVAIDYI NQNLPWGYKH TLNQIDEVKV WPQQPSGELF EIEIDTLETT CHVLDPTPVA RCSVRQLKEH AVEGDCDFQL LKLDGKFSVV YAKCDSSPDS AEDVRKVCQD CPLLAPLNDT RVVHAAKAAL AAFNAQNNGS NFQLEEISRA QLVPLPPSTY VEFTVSGTDC VAKEATEAAK CNLLAEKQYG FCKATLSEKL GGAEVAVTCT VFQTQPVTSQ PQPEGANEAV PTPVVDPDAP PSPPLGAPGL PPAGSPPDSH VLTVVQPSVG AAAGPVVPPC PGRIRHFKV
Endotoxin
< 0.1 ng/µg of protein (< 1EU/µg)
Purity
>95% by SDS-PAGE & HPLC analysis
Bioactivity
Determined by its ability to inhibit Cathespin V cleavage of a fluorogenic peptide substrate Z-LR-AMC (RLUs) . The expected IC50 is ≤ 100nM.
Length
309
Form
Lyophilized
Molecular Weight
45-55 kDa
Host or Source
HEK 293 cells

UniProtKB · P02765

Alpha-2-HS-glycoprotein

FETUA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02765
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
AHSG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A8K9N6, B2R7G1, O14961, O14962, Q9P152
Protein keywords

Technical term

Direct protein sequencingProteomics identificationReference proteome

Disease

Disease variantHypotrichosisIntellectual disability

PTM

Disulfide bondGlycoproteinPhosphoprotein

Biological process

Mineral balance

Domain

RepeatSignal

Cellular component

Secreted

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