Fetuin-A

• Description:

  Mouse Fetuin A, also known as α2-Heremans-Schmid glycoprotein, is encoded by the AHSG gene. It has been also called "countertrypsin" because of its ability to inhibit trypsin. It is a major plasma protein and a member of the cystatin superfamily of protease inhibitors. It is expressed by hepatocytes, the principal cell source, and by monocyte/macrophages. The major form of plasma Fetuin A corresponds to two disulfide bondlinked chains derived from the single chain. FetuinA has a number of functions. It is a negative acutephase protein with normal circulating levels in adults (300-600 μg/mL), which fall significantly (30-50%) during injury and infection. It enhances entry of cationic inhibitors into macrophages. It inhibits both insulin receptor autophosphorylation and undesirable calcification.

• Synonyms:

  Ahsg; fetuin-A

• NCBI Gene ID:

  11625

• UniProt:

  P29699

• Accession Number:

  NP_038493.1

• Accession Number mRNA:

  NM_013465.2

• Chromosomal Location:

  16 B1; 16 15.0 cM

• Reactivity:

  Anti-Mouse

• Cross Reactivity:

  Mouse

• Target Antigen:

  Recombinant mouse Fetuin-A

• Clone:

  (#4N42)

• Applications:

  WB

• Purification Method:

  Protein G/A chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Rat

• Isotype:

  IgG2