Fetuin-B

• Description:

  Fetuins are members of the cystatin superfamily of cysteine protease inhibitors. Additional members of this superfamily are kininogen and histidine-rich glycoprotein. Fetuin A and B are two known members of the fetuin family. Hepatocytes are believed to be the principal cellular source, but other cell types also express it. Fetuin A, also known as α2-Heremans-Schmid glycoprotein, is an inhibitor of basic calcium phosphate precipitation and a negative acutephase protein. Normal circulating levels of Fetuin A in adults (300-600 ug/mL) fall significantly (30-50%) during injury and infection. Fetuin A and B display similarities and differences in their characteristics. Fetuin B exhibits reduction of calcification, while both mRNA levels were downregulated during the acute phase in inflammation-induced rats. However, they share only 20% amino acid sequence identity. The amounts of Fetuin B in human serum, unlike Fetuin A, vary with gender and are higher in females than in males.

• Synonyms:

  FETUB; 16G2; Gugu; IRL685

• NCBI Gene ID:

  26998

• UniProt:

  Q9QX79

• Accession Number:

  NP_445800.1

• Accession Number mRNA:

  NM_053348.1

• Chromosomal Location:

  3q27

• Reactivity:

  Anti-Human

• Cross Reactivity:

  Human

• Target Antigen:

  Recombinant human Fetuin-B

• Clone:

  (#6N19)

• Applications:

  WB

• Purification Method:

  Protein G chromatography

• Assay Protocol:

  Centrifuge vial prior to opening. Reconstitute the antibody with 500 µl sterile PBS and the final concentration is 200 µg/ml.

• Form:

  Lyophilized

• Buffer:

  PBS

• Reconstitution:

  PBS

• Storage Conditions:

  Lyophilized samples are stable for 2 years from date of receipt when stored at -70°C. Reconstituted antibody can be aliquoted and stored frozen at < -20°C for at least six months without detectable loss of activity.

• Host or Source:

  Mouse

• Isotype:

  IgG1