Exodus-2 (CCL21)

• Description:

  Exodus-2 is a CC chemokine that signals through the CCR7 receptor. It is expressed in lymph nodes of certain endothelial cells, and in the spleen and appendix. Exodus-2 chemoattracts T and B lymphocytes and inhibits hematopoiesis. Exodus-2 contains six cysteine residues, including the four conserved cysteines present in CC chemokines. Recombinant human Exodus-2 is a 12.2 kDa protein containing 111 amino acid residues.

• Synonyms:

  CCL21; ECL; SLC; CKb9; TCA4; 6Ckine; SCYA21

• NCBI Gene ID:

  6366

• UniProt:

  O00585

• Accession Number:

  NP_002980

• Accession Number mRNA:

  NM_002989

• Chromosomal Location:

  9p13

• Reactivity:

  Human

• Cross Reactivity:

  Monkey, Mouse, Human, Leech, Pig

• Sequence:

  SDGGAQDCCL KYSQRKIPAK VVRSYRKQEP SLGCSIPAIL FLPRKRSQAE LCADPKELWV QQLMQHLDKT PSPQKPAQGC RKDRGASKTG KKGKGSKGCR KTERSQTPKG P

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract total lymphocyte population using a concentration range of 10.0-100.0 ng/ml.

• Length:

  111

• Form:

  Lyophilized

• Molecular Weight:

  12.2 kDa

• Host or Source:

  E. coli