Eotaxin-2 (CCL24)

• Description:

  Eotaxin-2 is a CC chemokine that signals through the CCR3 receptor. It is produced by activated monocytes and T lymphocytes. Eotaxin-2 selectively chemo attracts cells expressing CCR3 including eosinophils, basophils, Th2 T cells, mast cells, and certain subsets of dendritic cells. Additionally, Eotaxin-2 inhibits the proliferation of multi potential hematopoietic progenitor cells. The mature protein, which also includes a C-terminal truncation, contains 78 amino acid residues (92 a.a. residues for the murine homolog, without C-terminal truncation) . Recombinant human Eotaxin-2 is an 8.8 kDa protein containing 78 amino acid residues.

• Synonyms:

  CCL24; Ckb-6; MPIF2; MPIF-2; SCYA24

• NCBI Gene ID:

  6369

• UniProt:

  O00175

• Accession Number:

  NP_002982.2

• Accession Number mRNA:

  NM_002991

• Chromosomal Location:

  7q11.23

• Reactivity:

  Human

• Cross Reactivity:

  Mouse, Human, Bacteria

• Sequence:

  VVIPSPCCMF FVSKRIPENR VVSYQLSSRS TCLKGGVIFT TKKGQQFCGD PKQEWVQRYM KNLDAKQKKA SPRARAVA

• Endotoxin:

  < 0.1 ng/µg of protein (< 1EU/µg)

• Purity:

  > 98% by SDS-PAGE & HPLC analyses

• Bioactivity:

  Determined by its ability to chemoattract using human peripheral blood eosinophils using a concentration of 50-100 ng/ml.

• Length:

  78

• Form:

  Lyophilized

• Molecular Weight:

  8.8 kDa

• Host or Source:

  E. coli